Comparative Assessment of the Antiplasmodial Activity and Acute Toxicity of Schumanniophyton magnificum Good & Halle (Rubiaceae) Leaves, Trunk and Roots Methanolic Extracts

Background: Despite the various medicinal applications of Schumanniophyton magnificum, no comparative data are available to determine part with best antiplasmodial activity and guarantee its safety. This work deals evaluation methanolic extracts S. magnificum organs as well study acute toxicity most active part.
 Materials methods: The leaves, stem bark, trunk wood, root wood were obtained by maceration 96% methanol. Phytochemical screening, based on precipitation coloring reactions, highlight chemical groups present in plant. test was ran against chloroquine sensitive Plasmodium falciparum 3D7 strains while vivo conducted according guideline 423 OECD protocol at a fixed dose Wistar rats.
 Results: screening methanol these plants revealed presence alkaloids, triterpenoids, saponins, anthraquinones, polyphenols, coumarins anthocyanins flavonoids. showed that only leaves exhibited moderate effect IC50 30.77 µg/ml. An oral administration extract did not induce an abnormal variation physiological parameters female laboratory rats, non-toxic doses 50, 300 2000 mg/kg body weight for 14 days.
 Conclusion: antimalarial non toxic, thus justifying use plant treatment malaria traditional pharmacopoeia.
 Keywords: Antiplasmodial activity, Acute toxicity, Medicinal